Formulation of enteric coated microspheres containing pantoprazole

Authors

  • Xuan Truong Le Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city
  • Hue Minh Nguyen Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city
  • Ngoc Quynh Le Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city
  • Thi Thu Loan Trinh Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city
  • Van Thanh Tran* Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city

Keywords:

delayed release, enteric coated microsphere, pantoprazole

Abstract

Pantoprazole is a first-line proton pump inhibitor drug for the treatment of gastric acid secretion disorders that is known to have minimal side effects and drug interactions. To improve its stability in gastric acid, delayedrelease microspheres containing pantoprazole was prepared by emulsification-solvent evaporation using a polymer-containing mixture of hydroxypropyl cellulose (HPC) and ethyl cellulose (EC), which was then coated by alginate and Eudragit L100. The morphological characteristics of the microspheres were examined by SEM, the particle size distribution inferred by laser diffraction, and the physical state of drug substance was measured by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and in vitro drug release. The three formulations of microspheres chosen for this study had an average size of 100 µm. The dissolution profile showed less than 10% of the drug was released after 120 min in 0.1-M HCl and more than 75% of drug was released after 45 min in a phosphate buffer with a pH of 6.8.

DOI:

https://doi.org/10.31276/VJSTE.63(3).56-62

Classification number

3.3

Downloads

Published

2022-03-28

Received 23 October 2020; accepted 14 January 2021

How to Cite

Xuan Truong Le, Hue Minh Nguyen, Ngoc Quynh Le, Thi Thu Loan Trinh, & Van Thanh Tran. (2022). Formulation of enteric coated microspheres containing pantoprazole. Vietnam Journal of Science, Technology and Engineering, 63(3), 56-62. https://doi.org/10.31276/VJSTE.63(3).56-62

Issue

Section

Life Sciences