Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents
Keywords:
Biginelli reaction, deep eutectic solvents, green catalyst, green chemistryAbstract
A straightforward method for the preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by an acidic deep eutectic solvent from choline chloride (ChCl) and phenol via the Biginelli reaction of 2-aminobenzimidazole, ethyl acetoacetate, and aldehydes has been developed under metal- and solvent-free conditions. The desired products were obtained in moderate to good yield (49-79%) and the DESs were known as an economical and environmentally friendly catalyst.
DOI:
https://doi.org/10.31276/VJSTE.63(3).15-17Classification number
2.2

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Published
Received 20 March 2020; accepted 19 June 2020