Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents

Authors

  • Thuy-Duy Thi Nguyen Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh city
  • Anh Vy Truong DEDepartment of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh city
  • Hoang Phuong Tran Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh city

Keywords:

Biginelli reaction, deep eutectic solvents, green catalyst, green chemistry

Abstract

A straightforward method for the preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by an acidic deep eutectic solvent from choline chloride (ChCl) and phenol via the Biginelli reaction of 2-aminobenzimidazole, ethyl acetoacetate, and aldehydes has been developed under metal- and solvent-free conditions. The desired products were obtained in moderate to good yield (49-79%) and the DESs were known as an economical and environmentally friendly catalyst.

DOI:

https://doi.org/10.31276/VJSTE.63(3).15-17

Classification number

2.2

Downloads

Published

2022-03-28

Received 20 March 2020; accepted 19 June 2020

How to Cite

Thuy-Duy Thi Nguyen, Anh Vy Truong, & Hoang Phuong Tran. (2022). Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents. Vietnam Journal of Science, Technology and Engineering, 63(3), 15-17. https://doi.org/10.31276/VJSTE.63(3).15-17

Issue

Vol. 63 No. 3 (2021)

Section

Physical Sciences

License

This work is licensed under a Attribution-NonCommercial-NoDerivatives 4.0 International