Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents

Authors

  • Thuy-Duy Thi Nguyen
  • Anh Vy Truong
  • Hoang Phuong Tran

Abstract

Deep eutectic solvents (DESs) were first reported by Abbott and co-workers in 2001 and has since been widely applied to electrolytes, electrodeposition, electropolishing, ionothermal synthesis, gas adsorption, and biotransformation. DESs are classified as a new class of ionic liquids that present many outstanding characteristics such as low vapor pressure, nonflammability, easy preparation, low cost, and large recovery. DESs are classified as a new class of ionic liquids that present many outstanding characteristics such as low vapor pressure, nonflammability, easy preparation, low cost, and large recovery. These characteristics make DESs well-known as green solvents for organic transformations. These characteristics make DESs well-known as green solvents for organic transformations. The Biginelli reaction, first reported in 1891, played an important role in the synthesis of pyrimidine derivatives. A straightforward method for the preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by an acidic deep eutectic solvent from choline chloride (ChCl) and phenol via the Biginelli reaction of 2-aminobenzimidazole, ethyl acetoacetate, and aldehydes has been developed under metal- and solvent-free conditions. The desired products were obtained in moderate to good yield (49-79%) and the DESs were known as an economical and environmentally friendly catalyst.

Keywords:

Biginelli reaction, deep eutectic solvents, green catalyst, green chemistry

DOI:

https://doi.org/10.31276/VJSTE.63(3).15-17

Classification number

2.2

Author Biographies

Thuy-Duy Thi Nguyen

Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University - Ho Chi Minh City, 3 Ly Tu Trong Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam

Vietnam National University - Ho Chi Minh City, 3 Ly Tu Trong Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam

Anh Vy Truong

Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University - Ho Chi Minh City, 3 Ly Tu Trong Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam

Vietnam National University - Ho Chi Minh City, 3 Ly Tu Trong Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam

Hoang Phuong Tran

Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University - Ho Chi Minh City, 3 Ly Tu Trong Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam

Vietnam National University - Ho Chi Minh City, 3 Ly Tu Trong Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam

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Published

2021-09-15

Received 20 March 2020; revised 5 May 2020; accepted 19 June 2020

How to Cite

Thuy-Duy Thi Nguyen, Anh Vy Truong, & Hoang Phuong Tran. (2021). Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents. Vietnam Journal of Science, Technology and Engineering, 63(3), 15-17. https://doi.org/10.31276/VJSTE.63(3).15-17

Issue

Section

Physical Sciences