Chemical constituents and antimicrobial activity of Lisotrigona cacciae propolis collected in Hoa Binh province

Abstract

Propolis is a bee product that originates from plant resin and exhibits various biological activities and phytochemical compositions. Propolis products have been used as medicinal agents for centuries. Propolis has numerous health benefits stemming from its many pharmacological activities due to its antioxidant, antimicrobial, antiviral, anti-inflammatory, and anticancer properties. The chemical study on the propolis of the stingless bee Lisotrigona cacciae collected from Hoa Binh province led to the isolation of four compounds including cycloartenol (1), cochinchinone A (2), α-mangostin (3), and isomangiferolic acid (4). Mangifera indica (Xoài) and Cratoxylum cochinchinense (Thành Ngạnh Nam) were suggested to be the resin sources of the propolis. The propolis EtOH extract showed good antimicrobial activity against the Gram (+) strains B. cereus with an MIC value of 8 μg/ml. Among the isolated compounds, α-mangostin (3) was the most active and displayed strong activity against the five strains B. cereus, E. feacalis, S. aureus, P. aeruginosa, and the fungus C. albicans with MIC values of 1-2 μg/ml.