Neuroprotective effects of Diospyros kaki and Gardenia jasminoides against ischemic neuronal injury in mice

Authors

  • Thi Xoan Le* National Institute of Medicinal Materials
  • Thi Nguyet Hang Pham National Institute of Medicinal Materials
  • Van Tai Nguyen National Institute of Medicinal Materials
  • Viet Dung Le National Institute of Medicinal Materials

Abstract

This study aims to clarify the neuroprotective effects of ethanol extracts of Diospyros kaki (DK) leaves and Gardenia jasminoides (GJ) fruit on cerebral ischemia injury using middle cerebral artery occlusion (MCAO) model in mice. Swiss albino mice were daily treated with DK extract (125-500 mg/kg b.w) and GJ extract (250-1,000 mg/kg b.w) for 1 week before being subjected to MCAO. The administration of edaravone (6 mg/kg, i.v), which was a reference drug, was started immediately after MCAO. DK and edaravone treatment improved neurological deficits and reduced infarct volume of MCAO mice compared to that of a vehicle-treated one. GJ treatment improved neurological deficits, but did not affect the infarct volume of MCAO mice. These results suggested that the DK and GJ treatment might be beneficial for protecting the neuronal system against cerebral ischemic injury.

Keywords:

cerebral ischemia, Diospyros kaki, Gardenia jasminoides, middle cerebral artery occlusion, neuroprotection

DOI:

https://doi.org/10.31276/VJSTE.59(3).60

Classification number

3.3

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Published

2017-09-15

Received 8 May 2017; accepted 15 September 2017

How to Cite

Thi Xoan Le, Thi Nguyet Hang Pham, Van Tai Nguyen, & Viet Dung Le. (2017). Neuroprotective effects of Diospyros kaki and Gardenia jasminoides against ischemic neuronal injury in mice. Vietnam Journal of Science, Technology and Engineering, 59(3), 60-64. https://doi.org/10.31276/VJSTE.59(3).60

Issue

Section

Life Sciences