Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice

Authors

  • Hang Thi Nguyet Pham National Institute of Medicinal Materials, Vietnam
  • Hong Nguyen Tran National Institute of Medicinal Materials, Vietnam
  • Xoan Thi Le National Institute of Medicinal Materials, Vietnam
  • Khoi Minh Nguyen National Institute of Medicinal Materials, Vietnam
  • Hiep Tuan Nguyen National Institute of Medicinal Materials, Vietnam
  • Lap Thi Nguyen Hanoi Pharmacy University, Vietnam
  • Folk R. William University of Missouri, USA

Keywords:

Centella asiatica, dementia, hippocampus, neuroprotection, trimethyltin

Abstract

Centella asiatica (L.) Urb. is a nootropic that has been used medicinally for centuries. The present study investigates the anti-dementia effect of an n-butanol extract of Centella asiatica in a mouse model of neurodegeneration caused by trimethyltin (TMT). Mice were administered Centella asiatica extract (150 and 540 mg/kg) or a reference drug, tacrine (2.1 mg/kg), daily for one week before TMT injection and during tests to analyse spatial short-term and spatial working memory. The treatment of mice with TMT caused deficits in short-term spatial working memory and decreased the number of pyramidal cells in the hippocampal CA1 and CA3 regions elucidated by Nissl staining at 28 d post-TMT treatment. The administration of Centella asiatica extract or tacrine significantly attenuated the behavioural and histochemical changes caused by TMT. These results suggest that Centella asiatica extract improved memory deficits partly by protecting hippocampal neurons from TMT-induced damage.

DOI:

https://doi.org/10.31276/VJSTE.63(1).59-63

Classification number

3.3

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Published

2022-03-03

Received 2 October 2020; accepted 30 December 2020

How to Cite

Pham, H. T. N., Tran, H. N., Le, X. T., Nguyen, K. M., Nguyen, H. T. ., Nguyen, L. T., & William, F. R. (2022). Effect of Centella asiatica on cognitive deficits caused in trimethyltin-induced neurotoxicity model mice. Vietnam Journal of Science, Technology and Engineering, 63(1), 59-63. https://doi.org/10.31276/VJSTE.63(1).59-63

Issue

Section

Life Sciences