Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy

Authors

  • Thi Thanh Nhan Le
  • Thi Tu Linh Nguyen
  • Lan Phuong Le
  • Doan Thuy Nguyen
  • Van Lieu Nguyen
  • Thi Van Anh Nguyen
  • Hong Thai Trinh*

Abstract

Adverse drug reactions are a serious problem for health and one of the main reasons for treatment failure with antiepileptic drugs. In this study, we determined the HLA-DQB1 and -DPB1 alleles in the blood samples of 44 epileptic patients receiving carbamazepine treatment, including 21 patients with hypersensitivity and 23 patients with tolerance, using the next-generation sequencing method. We identified 19 HLA-DQB1 alleles, of which 13 were in the hypersensitive group and 15 were in the tolerant group. The frequency of the HLA-DQB1*03:01:01 allele was highest in both groups. Although the frequency of the HLA-DQB1*03:03:02 allele in the hypersensitive group was higher than that in the tolerant group (p=0.0431), this difference was not statistically significant after applying the Bonferroni correction (pc=0.5249). However, the evidence of in silico interaction between CBZ and HLA- DQB1*03:03 at the peptide-binding cleft was suggested. For HLA-DPB1, 16 alleles were found in epileptic patients, with the HLA-DPB1*05:01:01 allele having the highest frequency; however, no allele was associated with the risk of hypersensitivity to carbamazepine in epileptic patients. Our study demonstrates that the HLA-DQB1*03:03:02 allele tended to behave as a susceptibility factor for carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy.

Keywords:

carbamazepine, epilepsy, HLA-DPB1, HLA-DQB1*03:03:02

DOI:

https://doi.org/10.31276/VJSTE.2023.0041

Classification number

3.2, 3.5, 3.6

Author Biographies

Thi Thanh Nhan Le

VNU University of Science, Vietnam National University - Hanoi, 334 Nguyen Trai Street, Thanh Xuan Trung Ward, Thanh Xuan District, Hanoi, Vietnam

Thi Tu Linh Nguyen

VNU University of Science, Vietnam National University - Hanoi, 334 Nguyen Trai Street, Thanh Xuan Trung Ward, Thanh Xuan District, Hanoi, Vietnam

Lan Phuong Le

VNU University of Science, Vietnam National University - Hanoi, 334 Nguyen Trai Street, Thanh Xuan Trung Ward, Thanh Xuan District, Hanoi, Vietnam

Doan Thuy Nguyen

Hanoi Medical University, 1 Ton That Tung Street, Khuong Thuong Ward, Dong Da District, Hanoi, Vietnam

Tam Anh Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam

Van Lieu Nguyen

Hanoi Medical University, 1 Ton That Tung Street, Khuong Thuong Ward, Dong Da District, Hanoi, Vietnam

Tam Anh Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam

Thi Van Anh Nguyen

VNU University of Science, Vietnam National University - Hanoi, 334 Nguyen Trai Street, Thanh Xuan Trung Ward, Thanh Xuan District, Hanoi, Vietnam

Hong Thai Trinh

VNU University of Science, Vietnam National University - Hanoi, 334 Nguyen Trai Street, Thanh Xuan Trung Ward, Thanh Xuan District, Hanoi, Vietnam

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Published

2024-12-15

Received 8 May 2023; revised 6 July 2023; accepted 10 April 2024

How to Cite

Thi Thanh Nhan Le, Thi Tu Linh Nguyen, Lan Phuong Le, Doan Thuy Nguyen, Van Lieu Nguyen, Thi Van Anh Nguyen, & Hong Thai Trinh. (2024). Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy. Vietnam Journal of Science, Technology and Engineering, 66(4), 91-101. https://doi.org/10.31276/VJSTE.2023.0041

Issue

Section

Life Sciences

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