Several prognosis factors of severe pertussis in children treated at Vietnam National Children’s Hospital (2019-2020)

Abstract

A prospective, descriptive study was conducted on 382 pediatric patients diagnosed with pertussis at Vietnam National Children’s Hospital over a two-year period, from January 1^st, 2019, to December 31^st, 2020. Of all patients participating in this study, children with severe conditions accounted for 30.1% (115/382). Several factors were found to be associated with the risk of this condition with odds ratios (OR) and 95% confidence intervals (CI), including a decrease in the duration of the onset phase by 5 days [OR 1.53, 95% CI: 1.002-2.34], fever [2.49, 1.18-5.24], cyanosis [9.59, 2.9-31.7], pneumonia [14.45, 6.06-34.5], pulmonary hypertension [4.15, 1.02-16.83], an increase of 10 g/l in white blood cell (WBC) count in the full blood count (FBC) test [1.39, 1.05-1.84], a 5-cycle reduction in Cycle threshold (Ct) value in the pertussis real-time PCR test [1.36, 1.01-1.84], and superinfection [3.94, 1.84-8.48 times]. A WBC count in FBC of ≥30 g/l could be used as a prognostic factor for the risk of severe illness condition (sensitivity 46.1%, specificity 90.6%), the requirement for mechanical ventilation (sensitivity 57.1%, specificity 88.5%), and mortality (sensitivity 100%, specificity 91%).