Abstract
Fabrication and structural characterization of self-crosslinking hydrogel based on Vietnamese sources of chitosan and alginate
Tin Dai Luong1, 2, An Tran-My Le1, 2, Nhan Thien Vo1, 2, Thi Hiep Nguyen1, 2*
1School of Biomedical Engineering, International University, Ho Chi Minh city
2Vietnam National University, Ho Chi Minh city
Received 22 April 2022; accepted 11 July 2022
Abstract:
Hydrogel materials have attracted extensive research over the last few decades, especially in tissue engineering, due its many comparable properties with native tissue. This study proposes a new approach to hydrogel fabrication that combines oxidized alginate (OA) into N,O-carboxymethyl chitosan (NOCC) and an oxidized hyaluronan-based hydrogel system employing low cost, domestically sourced chitosan and alginate. Hydrogel fabrication parameters including component ratio and hydrogel concentration were studied. Fourier transform infrared spectroscopy (FT-IR) analysis was applied to confirm the chemical structure of the modified materials. Fabricated hydrogel samples were assessed by cross-sectional surface morphology, equilibrium swelling degree, and in vitro degradation behaviour. The results revealed NOCC and oxidized hyaluronic acid (OHA)-OA component contributions toward hydrogel properties, a threshold of raising total polymer content within the network, and a comparison with previous formulations using unmodified alginate. Using low cost domestic resources is a promising way to reduce fabrication expenses, and further work should be performed to evaluate the potential of this cost-effective hydrogel for the tissue engineering field.
Keywords: carboxymethyl chitosan, oxidized alginate, oxidized hyaluronan, self-crosslinking hydrogel,
Vietnamese materials.
Classification number: 3.6
