Chemical constituents and antimicrobial activity of Lisotrigona cacciae propolis collected in Hoa Binh province

Le Nguyen Thanh^{1, 2*} , Nguyen Phuong Thao³, Nguyen Tu Minh³, Trinh Khanh Huyen³, Vu Thi Kim Oanh^{1, 2}, Dinh Ngoc Thuc⁴, Tran Thi Ngat⁵, Nguyen Thi Phuong Lien⁵

¹Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

²Graduate Unversity of Science and Technology, VAST

³GATE Center, Vinschool

⁴Department of Scientific Management, Hong Duc University

⁵Institute of Ecological and Biological Resouces, VAST

Received 21 February 2020; accepted  15 May 2020

 

Abstract:

A chemical study on the propolis of the stingless bee Lisotrigona cacciae collected from Hoa Binh province led to the isolation of four compounds including cycloartenol (1), cochinchinone A (2), α-mangostin (3), and isomangiferolic acid (4). Mangifera indica (Xoài) and Cratoxylum cochinchinense (Thành Ngạnh Nam) were suggested to be the resin sources of the propolis. The propolis EtOH extract showed good antimicrobial activity against the Gram (+) strains B. cereus with an MIC value of 8 μg/ml. Among the isolated compounds, α-mangostin (3) was the most active and displayed strong activity against the five strains B. cereus, E. feacalis, S. aureus, P. aeruginosa, and the fungus C. albicans with MIC values of 1-2 μg/ml.

Keywords: antimicrobial activity, Lisotrigona cacciae, propolis, stingless bee, α-mangostin.

Classification number: 3.4