Vietnam Journal of Science, Technology and Engineering: March 2022 - Vol. 64 Number 1
The cover photo illustrates the result of osteogenic differentiation of adipose tissue-derived mesenchymal stem cells (AT-MSCs) under the effect of high D-glucose concentrations.
This study demonstrated that high D-glucose concentrations not only inhibited the proliferation but also impaired the osteogenic differentiation of AT-MSCs by suppressing the expression of osteogenic-specific genes Runx-2 and ALP. The knowledge gained from this study contribute to the understanding of the relationship between T2DM and osteoporosis, suggesting the role of stem cells in developing new medicine or therapeutic treatment for preventing diabetic complications.
To get more understanding about the topic, please see the full article " The impairment of osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells under high D-glucose concentrations" in pages 72-77 in this article.