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Sediment-water interaction is a complicated process; hence, it is essential to know the potential mobility of an element from sediment to the aquatic environment. In this study, the potential mobility of phosphorus (P) in sediment from Can Gio was investigated. Three single extractions were applied including a mild salt (NH4Cl), an acid (HCl), and a base (NaOH) each representing different environmental factors during sediment resuspension. Other geochemical parameters were also determined. The total amount of P in the sediments varied from 320.41 mg/kg to 668.22 mg/kg in five sampling sites. The general range of potential mobility of P decreased as follows: P-mild (3.70-13.13 mg/kg) < P-base (36.80-78.53 mg/kg) < P-acid (133.85-380.57 mg/kg). Although P-acid was not easily released to the environment, its relatively high concentration can affect the aquatic environment when the environment becomes acidic.