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The aim of this study was to study the use of a beads-based biofertilizer in crop production. The study focuses on the production of a beads-based biofertilizer containing spores and vegetative cells of Bacillus megaterium (B. megaterium) VACC 118. It also evaluated the quality of the biofertilizer and its effects on the growth and yield of cabbage. The results show that the density of B. megaterium in the beads-based biofertilizer reached 4.3x1010 CFU/g and did not change after 6 months of storage. The degree of swelling of the beads was 1.57 times after 24 hours of immersion in an alkaline solution. The number of released cells of B. megaterium reached 4.2x108 CFU/ml after 1 week of soaking in the alkaline solution. The application of the beads-based biofertilizer with NPK fertilizer increased the rate of folded plant, the fresh weight of head and the yield of cabbages grown in alluvial soil. When the beads-based biofertilizer was used along with a 20% reduction of the recommended NPK dosage, the yield of cabbage still increased by 12.36% compared to the control. This indicates that the beads-based biofertilizer can partially replace for chemical fertilizers.